DENVER -- Even when the San Francisco Giants pick up a rare win at Coors Field, they still lose. In this case, two pitchers -- starter Matt Cain and reliever Santiago Casilla, who both strained their right hamstrings and will undergo MRIs to determine the severity. Hunter Pence hit one of San Franciscos three solo homers and reliever Yusmeiro Petit threw three sharp innings after Cain left as the Giants beat the Colorado Rockies 5-1 on Wednesday night. "The win was great," Pence said, "but its a huge blow to lose Cain and Casilla." Pablo Sandoval and Brandon Crawford also connected for the NL West-leading Giants, who won at this hitter friendly venue for just the fifth time in 15 games dating back to last season. Cain had good command and was cruising along, not allowing a hit through three innings. Then, on his last pitch of the third, he felt a twinge in his hamstring. Casilla was hurt in the ninth inning when he tried to beat out an infield hit, falling over the bag and rolling several times on the field. He was helped to the dugout by the trainers and was replaced on the mound by Jeremy Affeldt, who finished the game. To think, just moments before in the dugout, Giants manager Bruce Bochy told Casilla to not even bother swinging -- just take it easy at the plate. "I was shocked he was running like that," Bochy said. "Guess he thought he had a hit. I dont know what got into him. Never seen him run like that." Petit (3-1) pitched effectively in Cains place as he and four other relievers limited the best offensive team in the majors to just five hits. Jhoulys Chacin (0-3) worked 5 2-3 innings and allowed three runs, including a homer to Pence in the fourth and another to Sandoval two innings later. "Two bad pitches, two homers, two runs," Chacin said. "I pitched good. We lost and thats all I care about." Crawford added a solo shot off Matt Belisle in the seventh as the Giants took the middle contest to even the three-game series. The Rockies have yet to lose a series at home this year. Trailing 5-0 in the eighth, the Rockies loaded the bases with no outs. Michael Cuddyer sent a grounder up the middle that Crawford tracked down and scooped over to second base with his glove to start a double play. Troy Tulowitzki then flew out limit the damage to only a run. Cain was settling into a rhythm when Rockies second baseman D.J. LeMahieu sent a sharp comebacker at the right-hander in the third. While the ball glanced off Cains glove, the Giants came out to check on him. Cain said after the game that had nothing to do with his hamstring injury. Earlier this season, Cain missed 13 games after he cut his right index finger while making a ham-and-cheese sandwich in the Giants clubhouse. The cut didnt require stitches. Optimistic this injury will heal fast? "Well see how tomorrow it feels," Cain said. "Still got some adrenaline going. But its calming down." Carlos Gonzalez also was banged up as he left the game as part of a double-switch in the eighth because of inflammation in his left index finger. He said he had an X-ray during the game and its not broken. "One of those things I have to deal with and get treatment every day," the slugger said. Tulowitzkis torrid hitting at home this season (.521 with eight homers) caught the attention of Giants broadcaster and former major league pitcher Mike Krukow. "Youre always skeptical -- its just the way you are as a player," Krukow said before the game. "Hes hitting as if hes getting signs. Im not accusing anybody of anything." Still, Rockies manager Walt Weiss had some fun with the assertion his shortstop is somehow stealing signs. "We have a light bulb on the scoreboard we flash. Keep an eye on Dinger (the teams mascot), hes involved," Weiss said. "We switch out the balls. Got the umpires in on it. "I love it when other teams talk about that," Weiss said. "I think its great. I think it feeds the beast." NOTES: Bochy said Buster Posey (nerve irritation in lower back) is "doing a lot better" and the catcher could be in the lineup Thursday. ... RHP Tim Hudson (4-2) will take the mound in the series finale on Thursday. The Rockies will throw LHP Jorge De La Rosa (5-3). Bradley Zimmer Jersey . Bach, a 59-year-old German lawyer, was elected Tuesday as president of the International Olympic Committee. He succeeds Jacques Rogge, who stepped down after 12 years. Bach, the longtime favourite, defeated five candidates in a secret ballot for the most influential job in international sports, keeping the presidency in European hands. Custom Cleveland Indians Jerseys . -- Among the 31 players at the Montreal Canadiens rookie camp, none feels closer to cracking the NHL roster than right winger Aaron Palushaj. http://www.indianssale.com/indians-tyler-clippard-jersey/ . And fellow Leaf, Jake Gardiner, hiking in Whistler. Bob Feller Indians Jersey . Matt Carkner got back into the Ottawa lineup, and made his presence felt right away by settling his clubs score in a one-sided fight with Rangers forward Brian Boyle. Joe Carter Indians Jersey . The CFL will help tackle womens cancers by playing four special "CFL PINK" games this weekend.TORONTO -- The wife of Montreal Alouettes general manager Jim Popp is recovering after being bit by a shark. Popp posted pictures of his wife, Kim, with a stitched-up foot and punctured ankle after she was attacked by a shark during a vacation at Hilton Head Island, S.C. "My Super Hero wife Kimm, mother of 6, sweet as honey, tougher than steel.dddddddddddd Bit by shark in HHI. Odds: 1 in 11.5 million," Popp posted on an unverified Twitter account with the handle (at)BigDaddyMville. The Alouettes confirmed the account belongs to Popp and that the shark attack occurred. ' ' '